Voltage-gated Na + channels (VGSCs) are well known for mediating regenerative cell membrane
depolarization and conduction of electrical signalling in nerves and muscles. However, …

Although ion channels are increasingly being discovered in cancer cells in vitro and in vivo,
and shown to contribute to different aspects and stages of the cancer process, much less is …

… Fraser (London, UK) reported an increase in Na v 1.5 amplitude after acute oestrogen
application. Oestrogen is a steroid hormone known to be important during breast cancer …

… Koyutürk); Medical Research Council, UK (WJ Brackenbury); Pro Cancer Research Fund
(MBA Djamgoz, SP Fraser, … Note: SP Fraser and JKJ Diss contributed equally to this work. …

The term curriculum is familiar in school education, but more ambiguous in its usage in a
higher education context. Although it is frequently used in academic staff discussions, policy …

A two-part hypothesis has been tested, which proposes that (1) prostate cancer cells are
galvanotactic (ie respond to an electric field by moving directionally) and (2) voltagegated Na + …

The voltage-gated ionic currents of two rodent prostatic cancer cell lines were investigated
using the whole-cell patch clamp technique. The highly metastatic Mat-Ly-Lu cells expressed …

Ion channels are important for many cellular functions and disease states including cystic
fibrosis and multidrug resistance. Previous work in the Dunning rat model of prostate cancer …

Previous work suggested that functional voltage‐gated Na + channels (VGSCs) are expressed
specifically in strongly metastatic cells of rat and human prostate cancer (PCa), thereby …

Background Voltage‐gated Na + channel (VGSC) activity has been implicated in prostate
cancer (PC) metastasis. Although VGSCs can occur as multiple‐subunit assemblies, the α‐…