Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

The calpains are a conserved family of cysteine proteinases that catalyse the controlled
proteolysis of many specific substrates. Calpain activity is implicated in several fundamental …

… Bendezú and Martin [92] have recently shown that during mating an active Cdc42 complex
… Dudin & SG Martin 2012, unpublished data). The question of cell–cell fusion would merit …

Telomeric TG-rich repeats and their associated proteins protect the termini of eukaryotic
chromosomes from end-to-end fusions. Associated with the cap structure at yeast telomeres is a …

The mammalian Ku70 and Ku86 proteins form a heterodimer that binds to the ends of
double-stranded DNA in vitro and is required for repair of radiation-induced strand breaks and V(D)…

Cells normally grow to a certain size before they enter mitosis and divide. Entry into mitosis
depends on the activity of Cdk1, which is inhibited by the Wee1 kinase and activated by the …

The PAR-4 and PAR-1 kinases are necessary for the formation of the anterior–posterior (A–P)
axis in Caenorhabditis elegans 1 , 2 , 3 . PAR-1 is also required for A–P axis …

The critical period of weed control is the portion of the life cycle of a crop during which it must
be kept weed-free to prevent yield loss due to weed interference. The advent of herbicide-…

Vascular endothelial cell growth factors (VEGF)-A,-C and-D have potent angio and
lymphangiogenic functions in experimental models, although their role in the progression of human …

Microtubules regulate actin-based processes such as cell migration and cytokinesis, but
molecular mechanisms are not understood. In the fission yeast Schizosaccharomyces pombe, …