Remarkable gains have been made in global health in the past 25 years, but progress has
not been uniform. Mortality and morbidity from common conditions needing surgery have …

Importance Immune checkpoint inhibitors (ICIs) are now a mainstay of cancer treatment.
Although rare, fulminant and fatal toxic effects may complicate these otherwise transformative …

Every year, more than 2 million women worldwide are diagnosed with breast or cervical
cancer, yet where a woman lives, her socioeconomic status, and agency largely determines …

Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and
have been hypothesized to contribute to aging. We show that mice expressing a proofreading…

To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …

PURPOSE: To develop oxygen-induced retinopathy in the mouse with reproducible and
quantifiable proliferative retinal neovascularization suitable for examining pathogenesis and …

Background Since a national lockdown was introduced across the UK in March, 2020, in
response to the COVID-19 pandemic, cancer screening has been suspended, routine …

Background Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a
low tumor mutational burden and a 1-year overall survival of approximately 50% in patients …

A tumor-derived growth factor that stimulates the proliferation of capillary endothelial cells has
a very strong affinity for heparin. This heparin affinity makes it possible to purify the growth …

23% of the total global burden of disease is attributable to disorders in people aged 60 years
and older. Although the proportion of the burden arising from older people (≥60 years) is …