The pathogenesis of lupus nephritis
… , ribonucleoprotein, U1snRNP, ligates TLR7 to induce type I IFN release in plasmacytoid
dendritic cells, 15 a process that is tightly controlled by IL-1 receptor–associated kinase-M. RNA …
dendritic cells, 15 a process that is tightly controlled by IL-1 receptor–associated kinase-M. RNA …
[HTML][HTML] Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair
… Recent studies showed that treatment of cultured macrophages with M-CSF, but not GM-CSF,
shifts macrophages from antigen-presenting cells to subpopulation of IL-10-producing …
shifts macrophages from antigen-presenting cells to subpopulation of IL-10-producing …
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
…, JSA Esch, M Imai, JM Edelberg, H Rayburn, M Lech… - Nature medicine, 1999 - nature.com
CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …
Evaluating deep learning architectures for speech emotion recognition
Speech Emotion Recognition (SER) can be regarded as a static or dynamic classification
problem, which makes SER an excellent test bed for investigating and comparing various deep …
problem, which makes SER an excellent test bed for investigating and comparing various deep …
[HTML][HTML] Tissues use resident dendritic cells and macrophages to maintain homeostasis and to regain homeostasis upon tissue injury: the immunoregulatory role of …
M Lech, R Gröbmayr, M Weidenbusch… - Mediators of …, 2012 - hindawi.com
Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages.
A classification that sufficiently covers their phenotypic heterogeneity and plasticity …
A classification that sufficiently covers their phenotypic heterogeneity and plasticity …
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
Macrophages are central orchestrators of the tissue response to injury, with distinct macrophage
activation states playing key roles in fibrosis progression and resolution. Identifying key …
activation states playing key roles in fibrosis progression and resolution. Identifying key …
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation
…, SL Edelmann, R Gloury, N Martin, C Lohs, M Lech… - Nature …, 2014 - nature.com
Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T FH cells)
is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found …
is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found …
[HTML][HTML] High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development …
Drug development suffers from a lack of predictive and human-relevant in vitro models.
Organ-on-chip (OOC) technology provides advanced culture capabilities to generate …
Organ-on-chip (OOC) technology provides advanced culture capabilities to generate …
Macrophage phenotype controls long-term AKI outcomes—kidney regeneration versus atrophy
M Lech, R Gröbmayr, M Ryu, G Lorenz… - Journal of the …, 2014 - journals.lww.com
… -M mRNA expression in solid organs of healthy adult female C57BL/6 mice, which revealed
high IRAK-M … We next determined whether IRAK-M is present in immune or nonimmune cells …
high IRAK-M … We next determined whether IRAK-M is present in immune or nonimmune cells …
Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels
Techniques that allow cells to self-assemble into three-dimensional (3-D) spheroid microtissues
provide powerful in vitro models that are becoming increasingly popular—especially in …
provide powerful in vitro models that are becoming increasingly popular—especially in …