SB-525334 (6-[2-tert-butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline) has
been characterized as a potent and selective inhibitor of the transforming growth factor-β1 (TGF-…

The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory
neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid …

Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV)
and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …

Effect of thiopental on neurologic outcome following coronary artery bypass grafting. - Abstract
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Submarine hydrothermal vents are geochemically reactive habitats that harbour rich microbial
communities. There are striking parallels between the chemistry of the H 2 –CO 2 redox …

Chloroplasts were once free-living cyanobacteria that became endosymbionts, but the
genomes of contemporary plastids encode only ≈5–10% as many genes as those of their free-…

A new hypothesis for the origin of eukaryotic cells is proposed, based on the comparative
biochemistry of energy metabolism. Eukaryotes are suggested to have arisen through …

The growing human population and a changing environment have raised significant
concern for global food security, with the current improvement rate of several important crops …

All complex life is composed of eukaryotic (nucleated) cells. The eukaryotic cell arose from
prokaryotes just once in four billion years, and otherwise prokaryotes show no tendency to …

All life is organized as cells. Physical compartmentation from the environment and self–organization
of self–contained redox reactions are the most conserved attributes of living things, …