The pharmacology of carvedilol
RR Ruffolo Jr, M Gellai, JP Hieble, RN Willette… - European journal of …, 1990 - Springer
Carvedilol is a potent antihypertensive agent with a dual mechanism of action. At relatively
low concentrations it is a competitive β-adrenoceptor antagonist and a vasodilator, whereas …
low concentrations it is a competitive β-adrenoceptor antagonist and a vasodilator, whereas …
Tumor necrosis factor-α: a mediator of focal ischemic brain injury
…, B Arvin, RF White, A Miller, CL Webb, RN Willette… - Stroke, 1997 - Am Heart Assoc
Background and Purpose Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine that
rapidly upregulates in the brain after injury. The present study was designed to explore the …
rapidly upregulates in the brain after injury. The present study was designed to explore the …
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
RS Ames, HM Sarau, JK Chambers, RN Willette… - Nature, 1999 - nature.com
Urotensin-II (U-II) is a vasoactive ‘somatostatin-like’ cyclic peptide which was originally
isolated from fish spinal cords 1 , 2 , and which has recently been cloned from man 3 . Here we …
isolated from fish spinal cords 1 , 2 , and which has recently been cloned from man 3 . Here we …
Identification and in vivo efficacy of small-molecule antagonists of integrin αvβ3 (the vitronectin receptor)
WH Miller, RM Keenan, RN Willette, MW Lark - Drug Discovery Today, 2000 - Elsevier
The integrin α v β 3 is thought to play a key role in the initiation and/or progression of several
human diseases, including osteoporosis, restenosis following percutaneous transluminal …
human diseases, including osteoporosis, restenosis following percutaneous transluminal …
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
…, MI Townsley, JJ Lepore, RN Willette - Science translational …, 2012 - science.org
Pulmonary edema resulting from high pulmonary venous pressure (PVP) is a major cause
of morbidity and mortality in heart failure (HF) patients, but current treatment options …
of morbidity and mortality in heart failure (HF) patients, but current treatment options …
Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2
RN Willette, W Bao, S Nerurkar, T Yue, CP Doe… - … of Pharmacology and …, 2008 - ASPET
The transient receptor potential (TRP) vanilloid subtype 4 (V4) is a nonselective cation
channel that exhibits polymodal activation and is expressed in the endothelium, where it …
channel that exhibits polymodal activation and is expressed in the endothelium, where it …
Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy
…, GZ Feuerstein, RN Willette - Journal of Cerebral …, 1993 - journals.sagepub.com
The consequences of cerebral ischemia were studied in three different strains (BDF, CFW,
and BALB/C) of mice. The different strains exhibited significant differences in susceptibility to …
and BALB/C) of mice. The different strains exhibited significant differences in susceptibility to …
Genetic hypertension and increased susceptibility to cerebral ischemia
FC Barone, WJ Price, RF White, RN Willette… - Neuroscience & …, 1992 - Elsevier
A review of the sensitivity of genetically hypertensive rats to cerebral ischemia was presented
together with original data describing the systematic comparison of the effects of focal …
together with original data describing the systematic comparison of the effects of focal …
Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury
…, DT Thudium, X Ma, RN Willette… - Cardiovascular …, 2004 - academic.oup.com
Objective: To investigate the role of Rho A and Rho-kinase in acute myocardial ischemia/reperfusion
injury and the protective effect of Rho-kinase inhibitor, Y-27632 [(R)-(+)-trans-N-(4-…
injury and the protective effect of Rho-kinase inhibitor, Y-27632 [(R)-(+)-trans-N-(4-…
[PDF][PDF] Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.
P Ernsberger, R Giuliano, RN Willette… - … of Pharmacology and …, 1990 - researchgate.net
ABSTRACT ABBREVIATIONS: AP, arterial pressure; HR, heart rate; RVL, rostral
ventrolateral medulla; 3H-PAC,[3HJp-aminoclonidine; PNMT, phenylethanolamine N …
ventrolateral medulla; 3H-PAC,[3HJp-aminoclonidine; PNMT, phenylethanolamine N …