The mammalian heart has a remarkable regenerative capacity for a short period of time after
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …

… the lowest FP rate (0.03 FP per kb) and IDT the highest (0.07 FP per kb); however, given
the small number of FPs, the differences between assays were not statistically significant (P > …

Obesity enhances the risk for the development of type 2 diabetes and cardiovascular disease.
Loss in insulin sensitivity and diminished ability of muscle to take up and use glucose are …

Obesity is a predictor of diabetes and cardiovascular disease. One consequence of obesity
is dyslipidemia characterized by high blood triglycerides. It has been proposed that oxidative …

Background Over 15 inherited diseases are caused by expansion of triplet-repeats. Friedreich
ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat sequence in …

Background Targeted sequencing using oncopanels requires comprehensive assessments
of accuracy and detection sensitivity to ensure analytical validity. By employing reference …

We have recently demonstrated that catalase content in mouse cardiac mitochondria is
selectively elevated in response to high dietary fat, a nutritional state associated with oxidative …

10.7554/eLife.44674.001 Iron is essential for survival of most organisms. All organisms
have thus developed mechanisms to sense, acquire and sequester iron. In C. elegans, iron …

… comparisons test was used and statistically significant differences are noted (p<0.05, n = 5).
… Statistically significant differences are designated with an * (p<0.05, n = 5, ANOVA with a …

… To map D(p i , p f ) to H d × R using a conformal transformation, we can combine a map D(p
i , p f ) to a Rindler wedge of Minkowski space as above, with a map back to a region |T| < T 0 …