Fostering evidence-based decision-making in Canada: examining the need for a Canadian population and public health evidence centre and research network
… , 123 Logan Avenue, Toronto, ON M4M 2M9, E-mail: lori.kiefer@utoronto.ca Reprint
requests: CIHR-IPPH, Institute of Population and Public Health, Ste 207-L, Banting Building, …
requests: CIHR-IPPH, Institute of Population and Public Health, Ste 207-L, Banting Building, …
A systematic review of randomized controlled trials of interventions to improve the health of persons during imprisonment and in the year after release
…, I Binswanger, L Kiefer… - … journal of public …, 2015 - ajph.aphapublications.org
We systematically reviewed randomized controlled trials of interventions to improve the
health of people during imprisonment or in the year after release. We searched 14 biomedical …
health of people during imprisonment or in the year after release. We searched 14 biomedical …
Dynamics of rhenium photocatalysts revealed through ultrafast multidimensional spectroscopy
Conspectus Rhenium catalysts have shown promise to promote carbon neutrality by reducing
a prominent greenhouse gas, CO 2 , to CO and other starting materials. Much research …
a prominent greenhouse gas, CO 2 , to CO and other starting materials. Much research …
TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding
JA Schofield, EE Duffy, L Kiefer, MC Sullivan… - Nature …, 2018 - nature.com
RNA sequencing (RNA-seq) offers a snapshot of cellular RNA populations, but not temporal
information about the sequenced RNA. Here we report TimeLapse-seq, which uses …
information about the sequenced RNA. Here we report TimeLapse-seq, which uses …
Hydrogen bond network in the metal binding site of carbonic anhydrase enhances zinc affinity and catalytic efficiency
LL Kiefer, SA Paterno, CA Fierke - Journal of the american …, 1995 - ACS Publications
In metalloenzymes the side chains that ligand the metal ion are nested in a hydrogen bonding
network with other protein residues. In carbonic anhydrase II (CAII) the four zinc ligands, …
network with other protein residues. In carbonic anhydrase II (CAII) the four zinc ligands, …
Anti‐KIT antibody, barzolvolimab, reduces skin mast cells and disease activity in chronic inducible urticaria
D Terhorst‐Molawi, T Hawro, E Grekowitz, L Kiefer… - Allergy, 2023 - Wiley Online Library
… The volume of distribution in the terminal phase was 70.9 ± 7.1 ml/kg or approximately
4.9 L in a 70 kg human. There were no differences in PK parameters between CU and SD …
4.9 L in a 70 kg human. There were no differences in PK parameters between CU and SD …
Survival advantage of combined chemoradiotherapy compared with resection as the initial treatment of patients with regional pancreatic carcinoma: an outcomes trial
…, A Cooperman, J Paradiso, L Kiefer - … Journal of the …, 2000 - Wiley Online Library
BACKGROUND Resection of pancreatic carcinoma is resource‐intensive with a limited
impact on survival. Chemotherapy and/or radiotherapy (RT) have been shown to be effective …
impact on survival. Chemotherapy and/or radiotherapy (RT) have been shown to be effective …
Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia
…, J Beitz, G Chen, XH Chen, E Duffy, L Kieffer… - Clinical cancer …, 2001 - AACR
… Calicheamicin γ l I is a potent cytotoxic enediyene antibiotic, originally isolated from
Micromonospora echinospora ssp. Calichensis. This antibiotic is believed to be released inside the …
Micromonospora echinospora ssp. Calichensis. This antibiotic is believed to be released inside the …
Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites
LL Kiefer, CA Fierke - Biochemistry, 1994 - ACS Publications
June 28, 1094® abstract: Carbonic anhydrase II (CAII) contains a conserved Hist zinc polyhedron
which is essential for catalysis. Removal of any one of the His ligands by replacement …
which is essential for catalysis. Removal of any one of the His ligands by replacement …
Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II
C Huang, CA Lesburg, LL Kiefer, CA Fierke… - Biochemistry, 1996 - ACS Publications
Direct metal ligands to transition metals in metalloproteins exert a profound effect on protein−metal
affinity and function. Indirect ligands, ie, second-shell residues that hydrogen bond to …
affinity and function. Indirect ligands, ie, second-shell residues that hydrogen bond to …