Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD).
However, cohorts and methods used to determine such rates are heterogeneous, …

… BARTLETT is a Professor of Medical Statistics at the London School of Hygiene & Tropical
Medicine, UK. TIM P. MORRIS is Principal Research Fellow in Medical Statistics at the MRC …

Clinical practice involves measuring quantities for a variety of purposes, such as aiding
diagnosis, predicting future patient outcomes, and serving as endpoints in studies or randomized …

Multivariate imputation by chained equations (MICE) is commonly used for imputing missing
data in epidemiologic research. The “true” imputation model may contain nonlinearities …

Missing covariate data commonly occur in epidemiological and clinical research, and are
often dealt with using multiple imputation. Imputation of partially observed covariates is …

Background Serial MRI scanning of autosomal dominant mutation carriers for Alzheimer's
disease provides an opportunity to track changes that could predate symptoms or clinical …

Volume and change in volume of the hippocampus are both important markers of Alzheimer's
disease (AD). Delineation of the structure on MRI is time-consuming and therefore reliable …

Objectives: We hypothesized that CSF neurofilament light (NFL) levels would be elevated in
dementias with subcortical involvement, including vascular dementia (VaD), but less …

Background Multiple imputation is often used for missing data. When a model contains as
covariates more than one function of a variable, it is not obvious how best to impute missing …

Despite growing clinical and neurobiological interest in the brain mechanisms that process
emotion in music, these mechanisms remain incompletely understood. Patients with …