Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1
T Shimada, CL Hayes, H Yamazaki, S Amin, SS Hecht… - Cancer research, 1996 - AACR
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae,
and the microsomes containing P450 1B1 were used to examine the selectivity of this …
and the microsomes containing P450 1B1 were used to examine the selectivity of this …
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.
CL Hayes, DC Spink, BC Spink… - Proceedings of the …, 1996 - National Acad Sciences
The 4-hydroxy metabolite of 17 beta-estradiol (E2) has been implicated in the carcinogenicity
of this hormone. Previous studies showed that aryl hydrocarbon-receptor agonists induced …
of this hormone. Previous studies showed that aryl hydrocarbon-receptor agonists induced …
Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.
TR Sutter, YM Tang, CL Hayes, YYP Wo… - Journal of Biological …, 1994 - Elsevier
Previously, levels of a novel human mRNA, detected by a recombinant cDNA designated
clone 1, were shown to be increased 50-fold in response to treatment of a keratinocyte cell line …
clone 1, were shown to be increased 50-fold in response to treatment of a keratinocyte cell line …
Tissue response to single‐polymer fibers of varying diameters: Evaluation of fibrous encapsulation and macrophage density
JE Sanders, CE Stiles, CL Hayes - Journal of biomedical …, 2000 - Wiley Online Library
An in vivo study was conducted to assess the sensitivity of fibrous capsule thickness and
macrophage density to polymer fiber diameter. Single polypropylene fibers of diameters …
macrophage density to polymer fiber diameter. Single polypropylene fibers of diameters …
[HTML][HTML] Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis
CL Hayes, J Dong, HJ Galipeau, J Jury, J McCarville… - Scientific reports, 2018 - nature.com
The intestinal barrier encompasses structural, permeability and immune aspects of the gut
mucosa that, when disrupted, may contribute to chronic inflammation. Although gnotobiotic …
mucosa that, when disrupted, may contribute to chronic inflammation. Although gnotobiotic …
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
…, A Caminero, G Rueda, CL Hayes… - Science translational …, 2020 - science.org
Metabolism of tryptophan by the gut microbiota into derivatives that activate the aryl
hydrocarbon receptor (AhR) contributes to intestinal homeostasis. Many chronic inflammatory …
hydrocarbon receptor (AhR) contributes to intestinal homeostasis. Many chronic inflammatory …
Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950
JMM Natividad, CL Hayes, JP Motta… - Applied and …, 2013 - Am Soc Microbiol
The intestinal microbiota is a key determinant of gut homeostasis, which is achieved, in part,
through regulation of antimicrobial peptide secretion. The aim of this study was to determine …
through regulation of antimicrobial peptide secretion. The aim of this study was to determine …
The effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17β-estradiol 4 …
DC Spink, CL Hayes, NR Young, M Christou… - The Journal of steroid …, 1994 - Elsevier
Rates of microsomal 17β-estradiol (E 2 ) hydroxylation at the C-2, -4, -6α, and -15α
positions are each induced greater than 10-fold by treating MCF-7 breast cancer cells with 2,3,7,8-…
positions are each induced greater than 10-fold by treating MCF-7 breast cancer cells with 2,3,7,8-…
Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times
LX Cai, K Pizano, GW Gundersen, CL Hayes… - Elife, 2020 - elifesciences.org
Dopamine (DA) neurons are thought to encode reward prediction error (RPE), in addition to
other signals, such as salience. While RPE is known to support learning, the role of salience …
other signals, such as salience. While RPE is known to support learning, the role of salience …
Genre knowledge and writing development: Results from the writing transfer project
…, J Paszek, G Gorzelsky, CL Hayes… - Written …, 2020 - journals.sagepub.com
Using a mixed-methods, multi-institutional design of general education writing courses at
four institutions, this study examined genre as a key factor for understanding and promoting …
four institutions, this study examined genre as a key factor for understanding and promoting …